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- David Azorsa, Ph.D. - Senior Investigator, Pharmaceutical Genomics, Translational Genomics Research Institute (TGen)
TITLE: "Application of Functional Genomics to Identify and Validate Genes That Restore Normal Cholesterol Transport in NP-C Cells"
- Robert Erickson, M.D. - Professor, University of Arizona
TITLE: "The Role of Curcumins as a Potential Therapy for NP-C Disease"
- Paul Helquist, Ph.D. and Olaf Wiest, Ph.D. - Professors, University of Notre Dame
TITLE: "Development of Therapeutic Agents for Niemann-Pick type C Disease"
- Barbara Karten, Ph.D. - Assistant Professor, Biochemistry and Molecular Biology, Dalhousie University in Halifax
TITLE: "The role of NPC1 in synaptic and neuronal function"
- Guosheng Liang, Ph.D. - Assistant Professor, UT Southwestern Medical Center at Dallas
TITLE: "Generation of Mouse Models to Elucidate the Tissue and Cell Type Specific Function of NPC1"
- Peter Lobel, Ph.D. - Professor, Pharmacology, Robert Wood Johnson Medical School
TITLE: "Molecular Characterization Niemann-Pick C2 Disease"
- Frederick Maxfield, Ph.D. - Professor and Chairman, Biochemistry, Weill Medical College of Cornell University
TITLE: "Modifiers of Cholestrol Transport in NPC Cells"
- Yoshiko Ohno-Iwashita, Ph.D. - Group Leader, Biomembrane Research Group, Tokyo Metropolitan Institute of Gerontology
TITLE: "Preparation of a high quality cholesterol-binding reagent, BC-theta"
- Daniel S. Ory, M.D. - Assistant Professor, Internal Medicine, Washington University
TITLE: "Role of PXR Activation for Neuroprotection in NPC"
- Suzanne Pfeffer, Ph.D. - Professor, Biochemistry, Stanford University School of Medicine
TITLE: "Molecular Analysis of NPC-1 Protein"
- Joyce Repa, Ph.D. - Assistant Professor, UT Southwestern Medical Center at Dallas
TITLE: "Nuclear orphan receptors as therapeutic targets for the treatment of Niemann-Pick Type C disease"
- Heiko Runz M.D. - Physician Scientist, Institute of Human Genetics, University of Heidelberg, Germany
TITLE: "Functional Characterization of candidate genes modifying NPC disease by cell-based RNAi-Arrays"
- Matthew Scott, Ph.D. - Professor, Developmental Biology, School of Medicine, Stanford University
TITLE: "Functions of the NPC1 Niemann-Pick Protein in Purkinje Neurons"
- Frances Sharom, Ph.D. - Professor and Canada Research Chair, Molecular and Cellular Biology, University of Guelph, Canada
TITLE: "Characterization of substrate binding, transport, lipid flippase and cholesterol transfer by the NPC1 protein"
Judith Storch, Ph.D. - Professor, Nutritional Sciences, Rutgers University
TITLE: "Mechanisms of NPC-2 protein in cholesterol transport"
- Gerrit van Meer, Ph.D. - Professor, Membrane Enzymology, Utrecht University, The Netherlands
TITLE: "NPC-1 pumping simple glycosphingolipids"
- Holly Goodson, Ph.D. and Kevin Vaughan, Ph.D. - Associate and Assistant Professors, Biological Sciences, University of Notre Dame
TITLE: "Microtubule-Dependent Transport of NPC-Containing Membranes"
- Steve Walkley, DVM, Ph.D. - Professor, Neuroscience, Albert Einstein College of Medicine
TITLE: "Gangliosides in the Pathogenesis of NP-C"
- Hongyuan Yang, Ph.D. - Senior Lecturer, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia
TITLE: "A Yeast model for studying NPC1 sterol transport"
- Silvana Zanlungo, Ph.D. - Assistant Professor, Gastroenterology, Pontificia Universidad Catolica de Chile
TITLE: "The proapoptotic c-Abl kinase as a therapeutic target for Niemann Pick Type C disease"
DART - Dana's Angels Research Trust of Greenwich, CT is co-funding and supporting the following scientists and research projects:
- Benny Liu, M.D. - NP-C 2-year Fellowship, UT Southwestern Medical Center at Dallas
TITLE: "Molecular events leading to cell death in the NPC syndrome"
- Kanagaraj Subramanian, Ph.D. - NP-C 2-year Fellowship, Scripps Research Institute
TITLE: "A Systems Wide Roadmap of NPC1 Mutant Trafficking in the Neuron"
- Charles Vite, D.V.M., Ph.D. - Associate Professor, Neurology, University of Pennsylvania School of Veterinary Medicine
TITLE: "Evaluating Treatment Strategies for Feline NPC Disease"
- Nicole Yanjanin, RN - Nurse Coordinator - NP-C Natural History Study, NIH
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