Ara Parseghian Medical Research Foundation
A Goal For Life
Research

Research

Currently Funded Grants as of 4/1/08

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  1. David Azorsa, Ph.D. - Senior Investigator, Pharmaceutical Genomics, Translational Genomics Research Institute (TGen)
    TITLE: "Application of Functional Genomics to Identify and Validate Genes That Restore Normal Cholesterol Transport in NP-C Cells"


  2. Robert Erickson, M.D. - Professor, University of Arizona
    TITLE: "The Role of Curcumins as a Potential Therapy for NP-C Disease"


  3. Paul Helquist, Ph.D. and Olaf Wiest, Ph.D. - Professors, University of Notre Dame
    TITLE: "Development of Therapeutic Agents for Niemann-Pick type C Disease"


  4. Barbara Karten, Ph.D. - Assistant Professor, Biochemistry and Molecular Biology, Dalhousie University in Halifax
    TITLE: "The role of NPC1 in synaptic and neuronal function"


  5. Guosheng Liang, Ph.D. - Assistant Professor, UT Southwestern Medical Center at Dallas
    TITLE: "Generation of Mouse Models to Elucidate the Tissue and Cell Type Specific Function of NPC1"


  6. Peter Lobel, Ph.D. - Professor, Pharmacology, Robert Wood Johnson Medical School
    TITLE: "Molecular Characterization Niemann-Pick C2 Disease"


  7. Frederick Maxfield, Ph.D. - Professor and Chairman, Biochemistry, Weill Medical College of Cornell University
    TITLE: "Modifiers of Cholestrol Transport in NPC Cells"


  8. Yoshiko Ohno-Iwashita, Ph.D. - Group Leader, Biomembrane Research Group, Tokyo Metropolitan Institute of Gerontology
    TITLE: "Preparation of a high quality cholesterol-binding reagent, BC-theta"


  9. Daniel S. Ory, M.D. - Assistant Professor, Internal Medicine, Washington University
    TITLE: "Role of PXR Activation for Neuroprotection in NPC"


  10. Suzanne Pfeffer, Ph.D. - Professor, Biochemistry, Stanford University School of Medicine
    TITLE: "Molecular Analysis of NPC-1 Protein"


  11. Joyce Repa, Ph.D. - Assistant Professor, UT Southwestern Medical Center at Dallas
    TITLE: "Nuclear orphan receptors as therapeutic targets for the treatment of Niemann-Pick Type C disease"


  12. Heiko Runz M.D. - Physician Scientist, Institute of Human Genetics, University of Heidelberg, Germany
    TITLE: "Functional Characterization of candidate genes modifying NPC disease by cell-based RNAi-Arrays"


  13. Matthew Scott, Ph.D. - Professor, Developmental Biology, School of Medicine, Stanford University
    TITLE: "Functions of the NPC1 Niemann-Pick Protein in Purkinje Neurons"


  14. Frances Sharom, Ph.D. - Professor and Canada Research Chair, Molecular and Cellular Biology, University of Guelph, Canada
    TITLE: "Characterization of substrate binding, transport, lipid flippase and cholesterol transfer by the NPC1 protein"


  15. Judith StorchJudith Storch, Ph.D. - Professor, Nutritional Sciences, Rutgers University
    TITLE: "Mechanisms of NPC-2 protein in cholesterol transport"


  16. Gerrit van Meer, Ph.D. - Professor, Membrane Enzymology, Utrecht University, The Netherlands
    TITLE: "NPC-1 pumping simple glycosphingolipids"


  17. Holly Goodson, Ph.D. and Kevin Vaughan, Ph.D. - Associate and Assistant Professors, Biological Sciences, University of Notre Dame
    TITLE: "Microtubule-Dependent Transport of NPC-Containing Membranes"


  18. Steve Walkley, DVM, Ph.D. - Professor, Neuroscience, Albert Einstein College of Medicine
    TITLE: "Gangliosides in the Pathogenesis of NP-C"


  19. Hongyuan Yang, Ph.D. - Senior Lecturer, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia
    TITLE: "A Yeast model for studying NPC1 sterol transport"


  20. Silvana Zanlungo, Ph.D. - Assistant Professor, Gastroenterology, Pontificia Universidad Catolica de Chile
    TITLE: "The proapoptotic c-Abl kinase as a therapeutic target for Niemann Pick Type C disease"

    DART - Dana's Angels Research Trust of Greenwich, CT is co-funding and supporting the following scientists and research projects:


  21. Benny Liu, M.D. - NP-C 2-year Fellowship, UT Southwestern Medical Center at Dallas
    TITLE: "Molecular events leading to cell death in the NPC syndrome"


  22. Kanagaraj Subramanian, Ph.D. - NP-C 2-year Fellowship, Scripps Research Institute
    TITLE: "A Systems Wide Roadmap of NPC1 Mutant Trafficking in the Neuron"


  23. Charles Vite, D.V.M., Ph.D. - Associate Professor, Neurology, University of Pennsylvania School of Veterinary Medicine
    TITLE: "Evaluating Treatment Strategies for Feline NPC Disease"


  24. Nicole Yanjanin, RN - Nurse Coordinator - NP-C Natural History Study, NIH

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© 2008 Ara Parseghian Medical Research Foundation
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